Judy Hopps waves goodbye to her family as she boards the train to Zootopia to join the city police force.
Mulan leaving home to take her father's place in the army.
Moana leaving Motonui for her quest to find Maui and restore the Heart of Te Fiti.
Rodney Copperbottom saying goodbye to his parents as he takes the train from Rivet Town to Robot City to meet Bigweld.
Danny Cat riding the bus to Hollywood to become a celebrity.
SpongeBob and Patrick driving off on the Patty Wagon to retrieve King Neptune's crown from Shell City and save Mr. Krabs.
The Mane Six and Spike leave Equestria to find help in regions beyond.
Garfield heading off to the big city to find and rescue Odie from Happy Chapman.
Buzz Lightyear heading off to find and rescue Woody with the help of Hamm, Rex, Mr. Potato Head and Slinky Dog.
Rob Rabbit leaves his hometown of Rabbit town and seeks adventures to get a job.
Anakin Skywalker leaving home to become a Jedi knight as he says goodbye to his mother, Shmi.
The Autobots led by Optimus Prime left their home planet of Cybertron in final days of the war in search for anything that can restore their homeworld while their enemies the Decepticons pursue them to Earth.
Kermit the Frog leaves his beloved swamp home and heads for Hollywood, California and become famous.
WALL-E leaves the abandoned Earth follow EVE (which she retrieves the plant) to the Axiom starliner.
Blue and her team leaving their fold to kill The Indominus Rex.
Twilight Sparkle and Spike the Dragon leaving their hometown of Canterlot (when ordered by her mentor, Princess Celestia) to Ponyville and make some new friends.
Timon leaving his home and sets off to live in his own life.
Buddy Hobbs leaves his adoptive hometown of Santa's Workshop to find his real father in New York City and teach him and the citizens the true meaning of Christmas.