Tragic Mistake

Tragic Mistake is the event where a hero is given a clear choice, but because they choose poorly, it results the disastrous event that brought the huge impact on their life that made them more miserable than ever. The said mistake may caused by the said hero's own flaws, but sometimes fate also pressed them to chooses poorly as well. While the hero and/or their allies may not realizing the consequence of their wrong choice, that moment is crucial to the beginning of unfortunate event that ranges from merely the hero's tragic downfall to the chain of disastrous events.

The results of this bad choice lead inexorably towards the hero's catastrophic end - had the hero chosen correctly at this point, the catastrophe could have been averted. The said mistake also the crucial part of their story.

Star Wars

 * Anakin Skywalker had made many mistakes prior to this point, but what pushed him irrevocably over to the Dark Side was his decision to save Emperor Palpatine instead of letting Windu execute him, leading directly to Mace Windu's death and leaving him no chance to go back as well as the downfall of the Jedi Order, including Order 66.
 * Another point of no return for Anakin was when he impulsively (and unnecessarily) refuses to see Padmé Amidala, trying to talk him down and Obi-Wan Kenobi stowing away on her ship, as anything but an attack on him. This results in him Force choking his wife and dueling with his former Jedi Master, ending with him having his three remaining limbs chopped off and getting burned very badly by lava. The old Anakin might have been able to find a way to save his wife from dying in her childbirth, but after waking up in the black suit, he realizes that his own fears ends up killing her.
 * Though Anakin is not necessarily blamed (again) even after his redemption and demise, the impact of both his and evil actions as Vader proved to be greater than either he or his son Luke expected: Ben, Luke's nephew and apprentice as well as Han Solo and Leia's son, whom upon learning Anakin's dark past as Darth Vader, decided to embrace the dark side and become Kylo Ren, causing a major setback on Luke's dream to restore Jedi Order to the point that he went to exile until Rey discovered him and give him hope.

Harry Potter

 * Harry Potter refuses to be taught Occlumency by Severus Snape because of their hatred and mistrust for each other where much to Harry's shock, their said hatred and mistrust for each other were caused by Snape's own bad history with James Potter long before James himself changed into better man due to his love with Lily. This allows Voldemort to send him a false vision of Sirius held captive so that Harry could run to his rescue. This results in the all-out fight that ends with Sirius' death since in his impulsiveness Harry also neglected a device which would have allowed him to communicate to Sirius immediately and verify that he's fine.
 * Prof. Snape himself also has of his own, where he ruined his friendship (and any chance for romance he might have had) with Lily when he chose the Dark Arts and became a zealous Death Eater. He then relayed a prophecy to Voldemort which causes him to target Lily's son, resulting in the murder of her and James. While he eventually decided to be the ally for Harry from there on, his own personal hatred with James winds up worsen his relationship with Harry until he eventually revealed his true agenda when Voldemort killed him for mistaking him as the master of Elder Wand that led Harry to forgive him. In certain point of view, had Snape put aside his difference with Harry (which in turn convinced Harry to do the same) from the moment where they met in Harry's first year in Hogwarts, he won't have to fail in taught Harry Occulumency that winds up resulting Sirius' death nor have hostilities that they had now at least until Snape seemingly murdered Dumbledore which actually done as mercy killing.
 * Among unfortunate mistakes that Albus Dumbledore ever done, the most tragic one was tempted to start a plot against Muggles with Grindelwald, and in his lust for power caused his sister's death when his brother confronted Grindelwald.
 * Horace Slughorn's was allowed the young Voldemort Tom Riddle to flatter him too much and revealed to him information about making seven Horcruxes for maximum power, which resulting deaths that the future Dark Lord required to create his said Horcruxes, Hagrid being reduced to the gamekeeper as the partially succeed framing attempt as means to cover his tracks and Lily's own death. Fortunately, he had the chance to redeem this through her son Harry whom working on helping Dumbledore' investigations.
 * Sirius Black was when he let Wormtail be the secret keeper to protect Potters, only for Wormtail betrayed them and brutally massacred innocent muggles and framed the crimes to him, resulting him sent to Azkaban until he uses his Animagus powers to escape. Another mistake would be mistreating his house-elf Kreacher, resulting the house-elf betrayed him and leaving him to die at hands of Bellatrix.
 * Albus Severus Potter and Scorpius Malfoy's attempt to alter the past to improved their current reality with a Time-Turner proved to be as the second attempt to alter the past resulting the bad future that only happened should Voldemort successfully killed Harry Potter. Though they managed to restore the reality back to when it previously was prior to their travel back in time, such attempt to undo what they did is not enough as Delphni, who revealed to be Voldemort's daughter that believed that Voldemort's defeat supposedly not happened, tries to save Dark Lord and it took their efforts and aid of their parents as well as Ron's family to stop her.
 * Percy Weasley's disowning his family of loyalty to the corrupted of Ministry of Magic, he even refuses to believe Harry Potter that Lord Voldemort has returned and Cedric Diggory murdered and Cornelius Fudge discredits him and Albus Dumbledore and informs that Cedric's death is a tragic accident. However after Cornelius Fudge is been overthrown by the wizarding community for lying of Voldemort's return, allowing Dolores Umbridge to became Headmistress of Hogwarts and Cedric's fate, he then realizes that Harry was right about Voldemort. He finally realizes his errors of his ways of his family after his brother Fred Weasley was killed in the Battle of Hogwarts and apologizes to his family for disowning them and avenges his brother.

Other

 * When Peter Parker arrogantly refused to stop for five seconds to stop a crook stealing the wrestling manager's money rushing past him, telling the cop chasing the guy it wasn't his job (along with the fact that the manager had cheated him out of the prize money just before the robber showed up), his life was changed forever; the same crook would later murder his uncle, Ben Parker. While that mistake defined what he is, the lesson was learned in the harshest way possible.

Live-Action Films and Television

 * The Asset: Unaware of his new environment, he makes the mistake of eating one of Elisa's cats and clawing Giles.
 * Carlito Brigante: Carlito's case mostly involving poor judge on a character that he supposedly either spare or not: Carlito had the troublemaking Benny Blanco at his mercy but let him live because he was a reformed man. Carlito also knew never to trust Pachanga and said he'd take care of him but he never found the time.
 * Claire Dearing: Claire's mistake that led her indirectly contribute destruction and deaths in Jurassic World at the hands of Indominus rex was her ignorance with the fact that dinosaurs actually have emotion and feelings instead of simply beasts with no intelligence as well and gives Owen a cold shoulder on her poor management on Indominus. That's until she realized that whatever treatment that she arranged for Indominus wind up destroyed what has left of her innocence where the hybrid killed many people by manipulating pterosaurs and raptors where Zach and Gray Mitchell nearly became the hybrid's victims as well as threatened the fate of the park.
 * Roger and Anita Radcliffe: When Roger and Anita go out for a walk to the park whilst taking Pongo and Perdita with them, they didn't take enough precaution in ensuring Pongo and Perdita's pups' safety from dalmatian kidnappers: Two bandits named Jasper and Horace Badun who are watching them from the shadows has study the whole situation in their house as they easily break in, lock Nanny in the cupboard, and stole the puppies without leaving traces. When they returned home, Roger and Anita feels saddened with what has happened and their mistakes that gave the thieves advantages. Fortunately, a group of farm animals whom knew where the thieves hiding at able to save the day by incapacitate the thieves includes their leader Cruella de Vill one by one not only to save Pongo and Perdita's puppies, but also other kidnapped homeless dalmatian puppies.
 * Rex (Babe): Rex was insulted at Babe's action of herding the sheep, he attacks Fly furiously injuring her leg. Arthur Hoggett sees this rushes to break them up, in his rage Rex accidentally bit his right hand in the process, causing Esme Hoggett to glare at him for it. When Babe tries to talk to him, he chases him away in anger, but he was held back by his leash with Arthur Hoggett witnessing him, calls the vet. The Vet then sedates him, losing his ability of herding the sheeps in the process. When Babe runs away thanks to Dutchess the Hoggett's nasty cat revealing to Babe that farmers eat pigs, Rex now realizes how Fly is heartbroken is without Babe and how much good he has done, regrets his behavior earlier, rushes to find Babe and probably scolds Dutchess furiously for saying those terrible words to Babe.
 * Chance: Chance has a fear of going to the "bad place". When Chance, Shadow and Sassy are been put into their cage at the airport by their owners so that they all could get board on the plane, Chance panics thinking that he and the others will be take to the pound despite Shadow's pleads that they will not take to the pound, he breaks free from his cage and foolishly returns to the airport lobby ultimately leading him and the others to be left behind.
 * Marty McFly: Marty buys a Sport Almanac book while in the future. Unknown to him that old Biff Tannen was watching him and steals the Delorean Time Machine, while he was helping his girlfriend Jennifer and Biff goes to the past and brings the Sport Almanac to his younger self, resulting alternative timelime which his father George Mcfly being murdered by Biff in 1973 and Emmett Brown declared insane and is committed. He was able to reverses Biff's change of the timeline with help from Emmett, thus returning everything back to truly was.

Disney/Pixar

 * Marlin: Out of his own fear over Nemo's safety and trauma over his loss by an agressive barracuda that massacred his eggs and killed his wife Coral, when he tries to advices Nemo to avoid the diver's boat, his overprotectiveness and fear get his best on him and resulting his son provoked to rebels and taken away by divers. Nemo managed to prevent him from repeating the same mistake when rescue Dory and unfortunate fishes whom snared by fishermen's net.
 * Mr. Potato Head: Despite that Andy Davis already missed Woody, he mistakes Woody for murdering RC who was actually trying to rescue Buzz Lightyear who was been attacked by Scud Sid Philip's dog and he orders the others to toss him overboard. While celebrating Bo Peep then see Woody riding in RC with Buzz, realizes that Woody was telling the truth. He then realizes what he has done and help them board their vehicle, though as retribution of his bad actions, he had to put himself back together due to RC accidentally crashed on him in Buzz and Woody's attempt to put him back into truck possibly as payback and punishment for the mutiny against Woody earlier and not realizing that Andy already missed Woody. He is then scolded by Buzz Lightyear for it after he requested for a rest during the rescue mission on Woody, after he was kidnapped by Al McWhiggen and he is still regretting it.
 * Anger: In a desperate attempt to make Riley happy again, Anger comes up with an idea of running away from San Francisco and return to Minnesota. However, the idea of running away proved to be a terrible mistake as the emotion console began shutting down and Riley was turned into an apathetic person without any feeling at all. When Joy and Sadness returned, Sadness was able to fix the console by removing the idea so Riley can change her mind.
 * Megara: Motions of events that led to Megara's heroic sacrifice that caused his current lover Hercules mourns over her dead body can be traced back from when she made a deal with Hades to save her first boyfriend's life (which in TV Series revealed as Adonis). Unfortunately, he later left her for some other woman, abandoning her and leaving her heartbroken and a prisoner of Hades. This traumatized her so much that she became bitter, though when finally met Hercules whom became her true love, she finally given chance to redeemed herself by sacrificing herself to save Hercules where the process not only to allowed the demigod to reclaimed his powers and freed her from her pact with Hades, but also resulting her demise. Fortunately, she later get better after revived by the demigod whom reclaimed her soul.
 * Mr. Incredible: Because he arrogantly detested Buddy Pine's attempt to aid him and recklessly saved a suicidal man whom doesn't wanted to be saved as well as disasters that he unintentionally caused, he not only forced all Supers to retire and into hiding (which somehow also decrease the crime rate), but also turned Buddy into the ruthless supervillain Syndrome whom sought to make the term "superheroes" redundant to the world which includes murdering huge number of Supers populate.
 * King Triton: Because he hated humans and learns that his daughter Ariel has fall in love to a human whom she saved from drowning that he loses his temper and begins destroying her collections and completely ignoring her pleads to stop, but he then realizes what he has done and leaves her in shame, this also lead Ariel to search of Ursula the SeaWitch.
 * Simba: Simba's that resulted Scar to usurp the rule over Pride lands as to listen Scar in the first place.
 * Mowgli: Mowgli realizes that Bagheera was right on how he ensured his safety from Shere Khan during the dire situation. He should go to the Man-Village to be safe from Shere Khan.
 * Sulley: Sulley's was letting out his signature roar to scare a robot child for simulation, which horrified Boo so much that she became too scared of him, which interfered their relationship.
 * Wreck-It Ralph: Ralph's was trying to earn himself a medal so that he would win the respect and hearts of other video game characters, especially the Nicelanders. But by doing so, he game jumped to Hero's Duty caused a lot of damage in his absence, his game was "Out of Order" and think that Mr. Litwack was planning on unplugging it if Ralph didn't come back. He also accidentally took one of the game's Cy-Bugs into Sugar Rush, whose candy allowed the bug to multiply itself into an enormous frenzy swarm of giant bugs with the potential to decimate the arcade.
 * Tarzan: Tarzan's of bringing the humans to the gorillas, caused him to fight the gorilla leader Kerchak just to protect his new friends, only to betray their family and disobey Kerchak's orders to protect their family, which leads him to renouncing his membership to the gorilla family, sadly discovering his true heritage that he is a human, saying goodbye to his adoptive mother Kala, as well as leading to the hunter Mr. Clayton to betray him, Jane and her father by setting the evil hunter's plan to capture the gorillas into motion.
 * Fa Zhou: He accepts the conscription notice from Chi-Fu who tells him to teach his daughter Mulan's tongue in a man's presence, after he silenced her and ignoring his injuries. While training his injuries prevented him. During dinner, he argues with Mulan that she need to learn her place like what he did, causing her run off in tears, but he ignores her and continues eating, his wife Fa Li and mother Grandmother Fa are saddened at his actions. Before going to bed, he comforts his wife, but she run off in tears, knowing he will not survive the war and realizing that Mulan takes his place and will be killed. After Shan Yu was finally killed and Chi-Fu resigning from his post to avoid facing trial for his crimes against Mulan after her identity is been exposed by Shan Yu by  ordering LI Shang to execute her, Fa Zhou was finally reunited with Mulan who presents him the Sword of Shan Yu and the Emperor's crest and he hugs her claiming that she is the greatest gift and honor.
 * Nakoma: Nakoma's of sending Kocoum after Pocahontas, resulted in the warrior getting killed by the settler Thomas, John Smith accused of Kocoum's murder, Pocahontas getting harshly blamed for her foolishness causing his death, and even leading to war between the Native Americans and the English Settlers.
 * Basil of Baker Street: He admitted that he let his ego get in the way after being humiliated by Ratigan and his gang, which showed he had a caring side, unlike Ratigan. Later on as he and Dawson lie on the trap, he sulked over his mistake of falling for Ratigan's trap.
 * Dr. David Q. Dawson: Basil apologized to him for yelling at him for not watching Olivia before she was kidnapped in the toy store by Fidget, taking her to Ratigan's lair.
 * Rabbit: He refused to make Easter, after Tigger stealed his role as Easter Bunny. When Spring cleaning has come and he wonders, where Pooh and the others are, thinking they're late and the narrator tells him that they're gone and move away. When he finally realizes after finding Roo's drawing of himself and Rabbit together, he now realizes that his friends (including Christopher Robin, Owl and Gopher) have moved away because of his selfishness and the next day, he realizes it's only a dream and still has a chance and prepares for the Easter and giving all of their easter things to them.
 * Darkwing Duck: Blinded by his own pride, arrogance and ego, Darkwing Duck stubbornly and rudely refused any assistance from the Justice Ducks (Steggmutt, Neptunia, Gizmoduck and Morgana) to fight against the Fearsome Five and insisted to take on the villains alone which however does not end well for him, he then realizes his mistake as his mistake as he learns that the Justice Ducks have been captured by the Fearsome Five.
 * Princess Atta: When P.T. Flea arrives in search of his troupe after he wrongfully fired them when their flaming act goes into disaster and exposes her the truth, she banishes them with Flik and orders him not to come back. This causes her sister Dot to become depress and heartbroken over her actions and she sadly calls to him, but he ignores her. When Hopper and his gang take over the island, Princess Atta has made a fatal mistake, she puts her entire colony in danger and leads the downfall her mother The Queen and without Flik their chance of getting rid of Hopper and his gang is lost. When Flik returns upon hearing Hopper's plan to squish The Queen by Dot and is beaten by Thumper thanks to P.T. Flea after he exposed the fake bird to Hopper, she defends him from Hopper and orders him to leave, resulting Hopper to get killed by the real bird putting his reign of terror and insult on the ant colony to an end.
 * Kuzco:  Pacha tries to warn Kuzco about Yzma and Kronk trying to kill him, only for Kuzco to blow him off, believing they were there to bring him back to the palace. He then orders Pacha to go away, believing  he's  the one trying to keep him from getting home. Only when Kuzco overhears the Yzma and Kronk talking about killing him does he realize he sent his only friend away for nothing.

DreamWorks

 * Shifu: Shifu's prior to events in Kung Fu Panda was during trained Tai Lung, he was so proud of his talent that he forgot to taught his said student humility, which contributes to the leopard's fall from grace when it's revealed that he was not meant to be Dragon Warrior. Master Oogway also pointed out that due to the said mistake, Tai Lung's arrogance turned into the very darkness that consume his heart and made him evil.
 * Alex the Lion: Alex's ignorance with life outside the zoo and lack of control over his feral side (which he recently discovered) counted as this, as it led him blinded by feral instinct to devour his own friend Marty (where he would've succeed had Julien not interfered).
 * The second that Alex done was when he listened to Makunga whom uses his lack of knowledge about cultures of his kind against him and his family(by lied to Alex that the fight with Teetsi would be dance contest, but in reality it was mortal kombat) as means to take over the pride.
 * However, Alex's very first was not entirely his fault, as Marty also shares the blame: Marty's own was in form of wish to go to the wild was without concerning his friends' well being, particulary Alex as well as not realizing that the wild is the place where carnivores won't hestitate to devour weaker animals.

Others

 * Terra: In Teen Titans 2003 TV Series, in a desperate attempt to control her earth powers, Terra chooses to join Slade whom promised her to trained her after failed to have Beast Boy keep this from other Titans, which turned out costs her friendship and love with Beast Boy.
 * Cameron Corduroy Wilkins: Cameron made a poor choice of refusing to trust Alejandro instead of accepting it when he was in a dangerous situation. After Cameron is eliminated from the competition due to injury, Gwen and Zoey say their goodbyes, Mike comes up to him and reveals himself to be Mal and he was the one who left him to fall. He should've listened to Alejandro earlier and would've known what was going on.
 * Wyatt: Wyatt's was his show-off habit not improved the trouble that he and his friends face, but rather worsen it instead.
 * SpongeBob SquarePants: In "The Legend of Boo-Kini Bottom", SpongeBob realizes the horror of their Patrick's so-called philosophy, "Scary equals funny" as it endangered the lives of his friends after the Flying Dutchman captures their souls and are holds them hostage.
 * Squidward Tentacles:
 * Steven Universe: Steven's which endangered his friendship with Garnet is refuses giving the mirror to her and in blind anger, hits Garnet in the heat of their argument.
 * Batman (The Lego Movie Series): He realizes in The Phantom Zone how big the mistake he made when he drove Dick, Barbara and Alfred.
 * Lapis Lazuli: Her decision to fuse and imprison Jasper in order to defeat her for good and save Steven's life becomes this in months until Alexandrite rescues her.
 * Bart Simpson: He has a nightmare and feels very guilty for burning Lisa's centerpiece, something which made him realized that it was a mistake and he must undo before it gets worse.
 * The Powerpuff Girls sad that they got so tempted by their new toys, they think the Professor is dead because of them, but in truth, he's alive, because there were only toy guns.
 * Littlefoot:
 * Cera: Cera's ego led to the death of the other dinosaurs and her friends being endangered from taking the wrong path. She however was too headstrong to admit her mistakes.
 * Topps: When the Thundering falls stop running due to the flying rocks blocking the water passage in the Mysterious Beyond, he gets an arguement with the other Great Valley inhabitors and need to take turns. When his daughter Cera is been bullied by Hyp and his gang by pushing Nod right into them with Cera getting out of the way and Littlefoot getting hurt by them, he thinks Littlefoot did waste the water calling him a bad influence which angers his grandfather and leading his long lost son-in-law Bron Littlefoot's father to dislike and hate him, when he learned this. When he gets an arguement with his Cera claiming the he only want what's best for her, heartbroken, she runs off. He even refuse to let a spike tail drinking from the river. After witnessing Hyp been scolded by his father for putting himself in danger, bullying his daughter and Littlefoot and his friends and leading Littlefoot getting insulted, he tells him not yell at him and shows what is right at what he care. After the Thundering falls finally returns when the block passage is clear, he apologizes for his behavior and earning Bron's trust when he finally meets him.
 * Beth Smith: She mistakenly shot Mr. Poopybutthole she thought he was an alien parasite.
 * Goldie: She mistakenly Edmond as the bad kitten that Pinky told her about and she shoos him away leading him to get captured along with Patou and the others by Pinky. She then realizes what she has done at seeing this and informs this to Chanticleer.
 * Barry B. Benson:
 * Dracula (Hotel Transylvania):
 * Twilight Sparkle: When she is at the mercy of Tempest Shadow, Twilight makes the mistake of failing friendship.
 * K.O.: In his haste to help Mr. Gar on a stakeout, K.O. ends up breaking open a sealed door to a secret cave filled with Glorbs, which is what Shadowy Figure had planned.
 * Mr. and Mrs. Turner: They mistakenly punish Timmy after Vicky tricked them into thinking that Timmy had vandalized their house, but after receiving pure evidence from "Deep Toot" (Tootie in disguise), they have finally discovered that Timmy was right about Vicky and that he was framed by her.

Anime and Manga

 * Tai Kamiya: When he was young, Tai Kamiya's younger sister, Kari, almost died due to his own negligence. Tai arrived home to find his sister (who was 4 or 5 at the time), staying home from kindergarten due to an illness. He took her outside to the playground to practice kicking the soccer ball, when she suddenly collapsed onto the ground. She was rushed to the hospital as her illness worsened, and Tai's mother, scolded and yelled at him for recklessly endangering his little sister's life. Kari remained in the hospital for weeks with possibly pneumonia, and almost didn't make it. When their parents finally brought her home from the hospital, Kari apologizes to her brother for not being to kick the ball very good, tells him that he'll never want to play with him again, causing Tai to break down in tears of guilt.
 * Ash Ketchum: In Pokémon Scent-sation! - He believes that perfume is a waste of money, which gets him kicked out of the shop for being very rude. Worse, the same people working in the shop work in the Celadon Gym and also forbid him from challenging Erika, the Gym Leader. Then he asked for Team Rocket's help to get in; but after James, Jessie and Meowth escape with the perfume formula, they blew up the Gym by detonating a bomb. Ash realizes he made a terrible mistake and feels very guilty, he should've apologized instead of sneaking in.
 * Alain: When Alain began his journey as a trainer and met up with the Team Flare leader, Lysandre, he was told that his team is using Mega Evolution energy to protect the Kalos region to be the strongest and help Chespie's recovery. He was later told to capture the Zygarde core whom they've called Z-2. However, when Team Flare attacked Lumiose City and abducted Ash after the Kalos League, Alain came to realize that everything Lysandre and his team ever told him were lies as they manipulated him to gather the Mega Evolution energy to recreate to world with Zygarde under their control. Alain felt betrayed by them and began to feel a great sense of guilt in him as he collapsed in frustration and anger. It wasn't entirely his fault, he was only doing this for Mairin and Chespie's sake as he never meant to hurt anyone.
 * Sayaka Miki: Though it could be said that Sayaka Miki's deal with Kyubey in the first place is the mistake that leads to her downfall, her actual act of Hamartia is when she refuses to cleanse her Soul Gem, because she's full of despair from seeing Kyousuke Kamijou (her childhood friend) accepting Hitomi Shizuki's love confession. Her despair not only turns her into a witch, but also leads to her and Kyouko Sakura's death.
 * Harogumo Ootsutsuki: He realized that he has done this by having Asura as his one and only successor, unknowingly allowed Black Zetsu worsened the rivalry between Asura and Indra that would lasts for generations everytime they reincarnated into their descendants. This ultimately undone with the brothers' latest incarnation, Naruto and Sasuke, eveuntually ended their feud for good.
 * Shinji Ikari: Shinji Ikari's is refuse to do anything when dealing Evangelion Unit-03 when realized that there's a pilt that trapped inside (Toji in original anime and manga of Neon Genesis Evangelion while Asuka in remake), provoke his father Gendo to activate his Eva's dummy system against his wishes that resulting Bardiel killed with its occupant injured/killed. However, the true was when hoping he can improved his relationship with his father Gendo, as ever since Gendo abandoned him, they have doomed to can never rekindle whatever family relationship that they had.
 * Edward and Alphonse Elric: A that started it all: Edward and Alphonse tried to performed alchemy to revived their deceased mother, but something went wrong which resulting Edward loses one of his arm and his leg while Alphonse lost his whole body that his soul embedded on a huge suit of armor to keep him alive. That is what started their journey for potent Philosopher Stone to undo damages that done to their bodies as well as made them sensitive about it. In fact, Edward would extremely angry toward alchemist whom went the path (breaking laws of alchemy) that made them suffer but indifferent with error that they done and even take pleasure from it, such as Shou Tucker.

Live Action TV

 * Dean Winchester: Threatened his brother Sam that he would sever their bonds and walked away from his life as means to convinced him not to drink more demon blood and abandoned Ruby so Lucifer won't free, but backfires with Sam became succumbed with her influence. When Dean decided to rekindle their relationship, he was unable to prevent Sam from freed Lucifer.
 * Castiel believed that he doesn't need Winchesters' help when tries to settle things right in Heaven since many angels prefer to start-off apocalypse, he resort to seek the cooperation from demon for the gateway of Purgatory, kills several angels whom happened to be in his way, and absorbs every single one of souls in Purgatory to put an end of the civil war. He even decided to took over God's role over the management of the universe, only to realized that Leviathans, whom he accidently absorbed, used him as means to entered Earth and killed him from the inside.

Video Games

 * Reasons why Kessler, Cole's alternate future self goes back in time to hardened his past self's life was due to his where he chooses to flee along with his family when The Beast emerges and killed all life in spite the fact he actually have powers to fought him, resulting Kessler the last lifeform on earth due to The Beast's rampage.
 * Dante Aligheri: Though his actions heinous enough to be considered as MEH, it's actually a that led Dante to redeem himself over the course of his journey in Hell to rescue Beatrice where the said mistakes are:
 * Having an affair with a whore that made him betrayed his love for Beatrice,
 * Allowed himself to be misguided by priest whom falsely claimed that his soul won't be damned during Crusade (the said priest's claim later revealed to be false due to killing is always a sinful act)
 * Angrily and selfishly killed captured non-Christian prisoner of war whom intended to be held for negotiation.
 * Tal'Set: After defeating the Campaigner, Tal'Set goes into a dream state where he and the other Turoks discuss from all times of period of the Chronoscepter's fate. He throws the weapon on the active volcano, so no one could use it. However this cause a violent earthquake all across through the Lost Lands and it awakens an evil entity called the Primagen from it's slumber.
 * Tifa Lockhart: She regrets of letting Aerith to rescue Barret's adopted daughter Marlene, allowing Shinra to capture Aerith.

Literature

 * Seerow: the Andalite Prince whom feels pity on Yeerks, parasitic slugs whom can only see, hear, or interact with their surroundings when possessed a creature, provided them Andalite Technology in hopes of making their life better. This unfortunately led the Cataclysmic event called Seerow's Kindness, where the evil Yeerks emerges and began their crusade for enslaving all lifeform as much as they could in the entire universe.

Quotes
"Fear: Guys, we can't make Riley feel anything. Anger: What have we done?"

- Anger realizing his tragic mistake which literally shuts down the console.

"Darth Sidious: Lord Vader... can you hear me? Darth Vader: Yes, Master. [Vader looks at Sidious] Where is Padme? Is she safe? Is she all right? Darth Sidious: It seems in your anger, you killed her. Darth Vader: I...? I couldn't have! She was alive... I felt it![Vader growls, and his Dark Side strength crushes everything around him in the room. He frees himself from the metal stretcher and steps off. The Emperor has a smirk on his face] Darth Vader: NOOOOOOOOOOOOOOOO!"

- Exchange between Vader and Sidious were Vader, formerly Anakin, realized that he ended up killing Padme

"Tigress: Shifu found him as a cub and he raised him as his son. And when the boy showed talent in kung fu, Shifu trained him. He believed in him. He told him he was destined for greatness. It was never enough for Tai Lung. He wanted the dragon scroll. But Oogway saw darkness in his heart and refused. Outraged, Tai Lung laid waste to the valley. He tried to take the scroll by force and Shifu had to destroy what he had created. But how could he? Shifu loved Tai Lung like he had never loved anyone before. Or since."

- Tigress explaining to Po about Shifu's tragic mistake in training Tai Lung was not to taught him humility, which resulted in him in becoming an arrogant and heartless villain.

"The dead remember our indifference; the dead remember our silence. I came here tonight to be congratulated. But today, when I visited the Red Cross camps, overwhelmed by the flood of refugees fleeing the horror of Kazakhstan, I realized I don't deserve to be congratulated. None of us do. The truth is, we acted too late. Only when our own national security was threatened did we act. Radek's regime murdered over 200,000 men, women and children and we watched it on TV. We let it happen. People were being slaughtered for over a year, and we issued economic sanctions and hid behind the rhetoric of diplomacy. How dare we? The dead remembered. Real peace is not just the absence of conflict, it's the presence of justice. Tonight I come to you with a pledge to change America's policy. Never again will I allow our political self-interest to deter us from doing what we know to be morally right. Atrocity and terror are not political weapons, and to those who would use them, your day is over. We will never negotiate. We will no longer tolerate and we will no longer be afraid. It's your turn to be afraid."

- President James Marshall revealing a tragic mistake that cost countless lives.

"Any sign of them? (Seahorse Herald:No, your majesty. We searched everywhere. We found no trace of your daughter or Sebastian.) Well, keep looking. Leave no shell unturned, no coral unexplored, and let no one in this kingdom sleep until she's safe at home! (Seahorse Herald [bowing his head]: Yes, sire. (leaves)) (King Triton sits on his throne with his hand on his face sadly and ashamed)Oh, what have I done? What I have done?"

- King Triton regretting his tragic mistake of destroying Ariel's grotto, her human collection and the statue of Prince Eric, leading her to run away with Sebastian and Flounder in search of Ursula the Sea Witch.

"Cera was still too proud to admit that she'd gone the wrong way."

- The Narrator describing Cera's mistake of not listening to her friends, and taking the wrong way to the Great Valley, nearly getting them killed.

"So we walked and walked. And just for an IittIe change of pace, we walked some more. Questions began racing through my mind. Where were we? How were we gonna get home? Who decided a Chihuahua was a dog? And, most importantly, when were we gonna eat?"

- Chance's tragic mistake of escaping from his cage while loading on the airplane leading him and the others to be left behind

"(Jane: Clayton betrayed us all. I'm so sorry, Tarzan!) No! I did this. I betrayed my family. Kerchak was right!"

- Tarzan's tragic mistake of leading the humans to his gorilla family, and betraying his family by disobeying Kerchak's orders.

"Wreck-It Ralph: Hello? Anybody home? Felix? Mary? (Gene: Well, you actually went and did it.) Ralph: Gene, where is everybody? (Gene: They're gone. After Felix went to find you and didn't come back, everyone panicked and abandoned ship.) Ralph: But...But I'm here now. (Gene: It's too late, Ralph. Litwak's pulling our plug in the morning.) (Ralph looks out the window and discovers there has been an 'Out Of Order' sign placed on the screen outside of the game during his absence.) (Gene: But never let it be said that I'm not a man of my word. The place is yours, Ralph. Enjoy.) (Gene throws Ralph the keys to the penthouse and turns to leave.) Ralph: Gene, wait! Wait! (Gene stops) Listen, this is not what I wanted. (Gene: Well, what did you want, Ralph?) Ralph: I don't know. I'm just... I was just tired of living alone in the garbage. (Gene: Well, now, you can live alone in the penthouse.) (Gene turns around and leaves Ralph all alone.)"

- Wreck-It Ralph realizing the error of his mistake of leaving his game.

"(Sandy: SpongeBob! Patrick! Help me!) [laughs] That almost looks like Sandy! [laughs] (Mr. Krabs: SpongeBob! Plankton: Patrick! Squidward: Help us! Gary: [meows forlornly]) sighs] That almost looked like Mr. Krabs and Squidward and Gary and Plankton. [laughs] Funny. Oh, Patrick, this is hysterical. [laughs] Why aren't you laughing? [laughs until he sees Patrick's body motionless] Patrick? What's wrong with you? (Patrick: Help me, SpongeBob! My body's butt itches!) Patrick? Is this really happening? Hey, this isn't funny. (Patrick: I was wrong, SpongeBob. Sometimes, scary equals scary!) (Patrick's motionless body falls on SpongeBob and he screams.) SpongeBob: Hm? (pulls out his chalkboard, erases the word "funny", and replaces it with "AHHH!") Yup. I got the same answer. Scary equals "Ahh!""

- SpongeBob realizing his tragic mistake when he finally sees that scary doesn't equal funny at all after his friends' souls were abducted and taken hostage by the Flying Dutchman.

"Oh, what have I done?"

- Goldie regreting his mistake, after witnessing Edmond and his friends being captured by Pinkie and his gang.

"(Alvin Seville: Simon, where’s Jeanette? She was out here with you.) Jeanette? I don’t know... (Brittany roll the ball to the stand, and talk to Simon.) (Brittany Miller: I do. It’s Zoe. She took her. Simon, I need to know where you found that gold bracelet.) What gold bracelet? (Brittany Miller: The one you gave to Jeanette.) What? Where do I give Jeanette a bracelet? (Brittany Miller: On your date.) (Simon gasps) Jeanette and I are dating?! (Brittany Miller: Okay, he’s useless.)"

- Simon’s tragic mistake that Jeanette and him are dating like who was alerted by spider bites and Brittany told him Jeanette has been taken by Zoe.

"(Mr. and Mrs. Turner have arrived at the parking lot of the Dimmadelphia Cafe.) (Mrs. Turner, looking at watch: It's 6:45. Where's Deep Toot?) (Mr. Turner giggles about the name until Mrs. Turner gives him a concerned look. Deep Toot arrives and the Turner Parents get out of the car.) (Mrs. Turner: Are you Deep Toot?) (Mr. Turner continues giggling, but stops) (Deep Toot: Yes I am. Your babysitter, Vicky. [slides the photo book of the evidence that Vicky has done] She's meaner than you know.) (Mrs. Turner picks up the book, and she and Mr. Turner look at the photos.) (Deep Toot: The vase, the picture, the piano. Vicky ruined them all and blamed Timmy.) (Mr. Turner, shocked: Hey, she's key scratching "Vicky was here" on my car. I punished Timmy for key scratching "Vicky was here" on my car. Why would she do that?) (Deep Toot: Some say it's to make parents say kids are horrible. They hire her more often.) (Mr. Turner: Leaping leg-holes. She's using my underwear to clog the toilet.) (Mrs. Turner: And I punished Timmy for that, by making him eat chocolate. Which in retrospect is it a very good punishment after all.) (Mr. Turner: Unless it's that reindeer chocolate.) (Deep Toot: Some say, me I think because she is evil. I think she's icky, icky with a V.) (The Turner Parents have discovered, for the first time, they have learned that their son, Timmy was right about Vicky.) (Mr. Turner: Wait a minute, Chip Skylark's hit song "Icky Vicky" suddenly makes sense!) (Mrs. Turner: Oh my gosh! Timmy was right. Vicky is terrible. Oh, Deep Toot, how can we ever thank- [pauses upon noticing that Deep Toot has disappeared without a trace]) (Mr. and Mrs. Turner have finally realized their mistake.) (Mr. Turner: She's gone!) (Mrs. Turner: We should've listened to Timmy!) (Mr. Turner: You have to tell him your sorry and wherever he is, wherever he's hiding, we know one thing for sure.) (Both: He's watching television! [head back into the car]) (Mr. Turner: [continues giggling] Deep Toot. [laughs] Oh, man. It kills me. Who was that girl, anyway?) (Mrs. Turner: I don't know, but she left this. [takes out the note that Deep Toot had left them before she disappeared] "I am not Vicky's sister.") (Mr. and Mrs. Turner become suspicious about the note from Deep Toot.)"

- Mr. and Mrs. Turner made a tragic mistake when they punished Timmy for vandalizing their house when Timmy tried to explained to them that Vicky is the actual culprit and that she is evil.

"(Andy's Toys except for Bo Peep celebrate their victory after throwing Woody off the moving truck and Lenny sees Woody at the distance.) (Lenny: Guys! Guys! Woody's riding R.C. and Buzz is with him.) (Bo picks up Lenny and sees that Buzz is alright.) (Bo Peep: It is Buzz! Woody was telling the truth!) (Andy's Toys, including Mr. Potato Head become guilty and horrified for what they did to Woody and realized that they should've listened to him in the first place and not realizing that Andy Davis already missed Woody.) (Slinky Dog, shocked: What have we done!) (Rex, guilty: Great, now I have guilt.)"

- Andy's Toys made a tragic mistake when they threw Woody off the moving truck to think he threw RC off when he was only trying to get Buzz Lightyear.

"(Roger and Anita Radcliffe are in the park sitting in a bench in a gazebo, Pongo and Perdita hear the pensioner's bulldog barking piercingly at Jasper and Horace who already escaped with the 15 puppies in tow) (Roger: I mean, I think-- (Pongo and Perdita run off) Pongo!) (Anita: Perdy!) (They follow them) (Nanny: Help, police! Where are they? (goes to the kitchen and finds the puppie's basket empty) Oh,no! They've taken the puppies! (hears Pongo and Perdita coming back) Anita! Roger! (rushes to the door and opens it, Pongo and Perdita enters) Thank god, they're home!) (Roger and Anita enters ) (Anita: Why? What is it?) (Nanny: The puppies! They were two men, they've stole the puppies! I tried to stop them. But they locked me in the cupboard. I shouted and shouted, but nobody came.) (Pongo and Perdita goes to the kitchen to find the basket completely empty and Roger and Anita enters horrified and saddened what they have done, they leave the 15 puppies completely unprotected and she and Pongo lay sadly down on the basket.)"

- Roger and Anita Radcliffe made a tragic mistake when they going out for a walk to the park taking Pongo and Perdita with them, they leave the 15 puppies unprotected, allowing Jasper and Horace to steal them while they are gone.

"(Pacha carries Kuzco out of the diner) What are you doing? (Pacha: Look, there's two people in there looking for you.) What? (Pacha: A big guy and a skinny old woman.) Wait. Was this woman scary beyond all reason? (Pacha: Oh, yeah.) That's Yzma and Kronk! I'm saved! (Pacha [grabbing Kuzco by the collar]: Trust me, they're not here to save you.) They'll take me back to the palace. Thanks for your help. You've been great. I can take it from here. (Pacha: No, no, you don't understand! They're trying to kill you!) Kill me? Their whole world revolves around me. (Pacha: No! I can't let you! [tries pulling Kuzco back]) What? Oh! Oh, I get it. (Pacha: What?) You don't wanna take me back to the palace. You wanna keep me stranded out here forever. (Pacha: No!) This has all been an act, and I almost fell for it. (Pacha: Will you just listen to me?) No, you listen to me! All you care about is your stupid hilltop! (Pacha: What?) You don't care about me, now just get out of here. Go! (Pacha: But--) Go on! Get outta here! (Pacha [angrily]: Fine!) (Kuzco turns his back on Pacha and makes his way to Yzma and Kronk.) (Yzma: Oh, this entire mess is all your fault!) (Kronk: What'd I do?) (Yzma: If you hadn't mixed up those poisons, Kuzco would be dead now! [At Yzma's statement, the smile on Kuzco's face instantly falls.] There'll be no more diversions until we track that llama down and kill him!) (Kuzco gasps in horror and hides in the bushes) (Kronk: Said I was sorry. Can't just let it go. Not even on your birthday.) (Yzma: Kuzco must be eliminated! The empire will finally be rid of that useless slug!) (Kronk: Well, you got a point. Nobody really seems to care that he's gone, do they?) (Kuzco stares in shock as he watches Yzma and Kronk leave.) Pacha! PACHA?! (Pacha has left, Kuzco slumps in despair)"

- Kuzco blowing off Pacha's warnings about Yzma and Kronk trying to kill him, believing that they were actually there to bring him back to the palace. He then tells Pacha to go away, believing his claim to be a plan to save his hilltop from destruction. Only when Kuzco overhears Yzma and Kronk talking about killing him does he realize he sent his only friend away for nothing.