Fails to Protect Everybody

When the heroes or heroines realize that they're too late or too busy with something, the main antagonist can distract or set a trap for the heroes while the bad guys destroy the city, hurting the people or kidnapped their loves ones which it's one of the toughest choice!

That lends the heroes anger, depressing or realize that it's their fault that they shouldn't listen to their friends or family member after it was too late.

Examples

 * Yami Moto fails to save Yugi, because his dark side took over his heart and Yugi's soul was taking away by sacrifice himself.